Schnelleinstieg Reader

Home|Suche|Friedolin|Webmail de

Wortmarke FSU

Prof. Dr. Dirk Hoffmeister


Publikationen - Publications

2012

Misiek, M.& Hoffmeister, D. (2012) Sesquiterpene aryl ester natural products in North American Armillaria species. Mycol. Prog. 11, 7-15.

Fernandez, E., Ruiz-Duenas, F.J., Ferreira, P.,  Floudas, D., Hibbett, D., Canessa, P., Larrondo, L.F., James, T., Seelenfreund, D., Lobos, S., Polanco, R., Tello, M., Honda , Y., Watanabe, T., Watanabe, T., Ryu, J.S., Kubicek, C.P., Schmoll, M., Gaskell, J., Hammell , K.E., St. John , F., Vanden Wymelenberg, A., Sabat, G., BonDurant, S.S., Syed, K., Yadav, J., Doddapaneni, H., Subramanian, V., Lavín, J.L., Oguiza, J.A., Perez, G., Pisabarro, A.G.,  Ramirez, L., Santoyo, F., Hori, C., Master, E., Coutinho, P.M., Henrissat, B., Lombard, V., Magnuson, J.K., Kües, U., Hori, K., Igarashi, K., Samejima, M., Barry, K., Lapidus, A., Lindquist,  E., Riley, R., Hoffmeister, D., Schwenk, D., Hadar, Y., Yarden, O., de Vries, R., Wiebenga, A., Stenlid, J.,  Eastwood, D., Grigoriev, I., Berka, R., Blanchette, R.A., Kersten, P., Martinez, A.T., Vicuna, R. & Cullen, D. (2012) Comparative genomics of wood decay fungi Phanerochaete chrysosporium and Ceriporiopsis subvermispora provides insight into mechanisms of selective ligninolysis. Proc. Nat. Acad. Sci. USA 109, 5458-5463.

Olson, Å., Brandström-Durling, M., Lind, M., Dalman, K., Himmelstrand, K., Karlsson, M., Lundén, K., Vélëz, H., Canbäck, B.,  Högberg, N., Asiegbu, F., Raffaello, T., Martin, F., Kohler, A.-G., Murat, C., Duplessis, S., Morin, E., Lombard, V.,  Coutinho, P., Henrissat, B., Solheim, H., Fossdahl, C.G., Yakovlev, I., Hietala, A., Rouzé, P., Lin, Y.-C., Kües, U.,  Grigoriev, I., Aerts, A., Lindquist E., Salamov, A., Lucas, S., Schmutz, J., Grimwood, J.,  Garbelotto, M., Hoffmeister, D.,  Park, J., Lee, Y.-H., Woodward, S., Deflorio,  G., James,  T., van Diepen, L., Ståhlberg, J., Cullen, D., Belbahri, L.,  De Vries, R., Bouzid, O., Wiebenga, A., Broberg, A., Hansson, D., Gonthier, P. & Stenlid J. (2012) Insight into trade-off between wood  decay and parasitism from the genome of a fungal forest pathogen. New Phytol. 194, 1001-1013.

Wackler, B., Lackner, G., Chooi, Y.H. & Hoffmeister, D. (2012) Characterization of the Suillus grevillei quinone synthetase GreA supports a nonribosomal code for α-keto acids. ChemBiochem (akzeptiert).

2011

M. Misiek, J. Braesel & D. Hoffmeister (2011). Characterisation of the ArmA adenylation domain implies a more diverse secondary metabolism in the genus Armillaria. Fungal Biol. 115(8), 775-781 D.C. Eastwood, D. Floudas, M. Binder, A. Majcherczyk, P. Schneider, A. Aerts, F.O. Asiegbu, S.E. Baker, K. Barry, M. Bendiksby, M. Blumentritt, P.M. Coutinho, D. Cullen, R.P. de Vries, A. Gathman, B. Goodell, B. Henrissat, K. Ihrmark, H. Kauserud, A. Kohler, K. Labutti, A. Lapidus, J.L. Lavin, Y.H. Lee, E. Lindquis, W. Lilly, S. Lucas, E. Morin, C. Murat, J.A. Oguiza, J. Park, A.G. Pisabarro, R. Riley, A. Rosling, A. Salamov, O. Schmidt, J. Schmutz, I. Skrede, J. Stenlid, A. Wiebenga, X. Xie, U. Kües, D.S. Hibbett, D. Hoffmeister, N. Högberg, F. Martin, I.V. Grigoriev & S.C. Watkinson (2011). The Plant Cell Wall-Decomposing Machinery Underlies the Functional Diversity of Forest Fungi. Science 333, 762-765 M.F. Kreutzer, H. Kage, P. Gebhardt, B. Wackler, H.P. Saluz, D. Hoffmeister & M. Nett (2011). The mic Locus in the Phytopathogen Ralstonia solanacearum Encodes the Biosynthesis of a Complex Yersiniabactin-like Natural Product. Appl Environ Microbiol. 77, 6117-6124

K. Baumgartner, M.P. Coetzee & D. Hoffmeister (2011). Secrets of the subterranean pathosystem of Armillaria. Mol Plant Pathol. 12(6), 515-534. B. Wackler, P. Schneider, J.M. Jacobs, J. Pauly, C. Allen, M. Nett & D. Hoffmeister (2011). Ralfuranone biosynthesis in Ralstonia solanacearum suggests functional divergence in the quinone synthetase family of enzymes. Chem Biol. 18(3), 354-360.

M. Bohnert, M. Miethbauer, H.M. Dahse, J. Ziemen, M. Nett, & D. Hoffmeister (2011). In vitro cytotoxicity of melleolide antibiotics: structural and mechanistic aspects. Bioorg. Med. Chem. Lett. 21, 2003-2006

2010

Hüttel, W., Hoffmeister, D. (2010). Chapter 14: Fungal bioconversions in pharmaceutical sciences. In: Hofrichter, U, Esser, K. (Eds.), The Mycota, Vol. X, 2nd  ed.; Springer (im Druck).

Bohnert, M., Wackler, B., Hoffmeister, D. (2010). Spotlights on advances in mycotoxin research. Appl. Microbiol. Biotechnol. 87, 1-7.

2009

Misiek, M., Williams J., Schmich, K., Hüttel, W., Merfort, I., Salomon, C., Aldrich, C.A., Hoffmeister, D. (2009). Structure and Cytotoxicity of Arnamial and Related Fungal Sesquiterpene Aryl Esters. J. Nat. Prod. 72, 1888-1891.

Schneider, P., Jacobs, J, Neres, J., Aldrich, C.A., Allen, C.Z., Nett, M., Hoffmeister, D. (2009) The global virulence regulators VsrAD and PhcA control secondary metabolism in the plant pathogen Ralstonia solanacearum, ChemBiochem 10, 2730-2732.

Hoffmeister, D., Bechthold, A. (2009). Giftpflanzen, Pilzgifte. In: Aktories, K., Förstermann, U., Hofmann, F., Starke, K. (Hrsg.), Repetitorium Pharmakologie und Toxikologie, 2. Aufl., Elsevier, 447-451.

Hoffmeister, D., Bechthold, A. (2009). Kapitel 37.12 und 37.13 (Giftpflanzen, Pilzgifte). In: Aktories, K., Förstermann, U., Hofmann, F., Starke, K. (Hrsg.), Pharmakologie und Toxikologie. 10. Auflage; Elsevier, (im Druck).

2008

Misiek, M., Hoffmeister, D. (2008). mRNA processing sites involved in intron splicing of Armillaria natural product genes. Mycol. Res. 112, 216-224.
Schneider, P., Weber, M., Hoffmeister, D. (2008). The Aspergillus nidulans enzyme TdiB catalyzes prenyltransfer to the precursor of bioactive asterriquinones. Fungal Genet. Biol. 45, 302-309.

Schneider, P., Bouhired, S., Hoffmeister, D. (2008). Characterization of the atromentin biosynthesis genes and enzymes in the homobasidiomycete Tapinella panuoides. Fungal Genet. Biol. 45, 1487-1496.

Schneider, P., Misiek, M., Hoffmeister, D. (2008). In vivo and in vitro production options for fungal natural products. Mol. Pharm. 5, 234-242.

2007

Hoffmeister, D. (2007). Kapitel 7: Grundlagen der Gentechnologie. In: Bechthold, A., Vollmar, A., Wagner, H., Pharmazeutische Biologie, 7. Auflage; Wissenschaftliche Verlagsgesellschaft, 285-322.

Misiek, M., Hoffmeister, D. (2007). Fungal genetics, genomics and secondary metabolites in Pharmaceutical Biology. Planta Medica 73, 103-115.

Schneider, P., Weber, M., Rosenberger, K., Hoffmeister, D. (2007). A one-pot chemoenzymatic synthesis to the universal precursor for antidiabetes and antiviral bis-indolylquinones. Chem. Biol. 14, 635-644.

Bouhired, S., Weber, M., Kempf-Sontag, A., Keller, N. P., Hoffmeister, D. (2007). Accurate prediction of the Aspergillus nidulans terrequinone gene cluster boundaries using the transcriptional regulator LaeA. Fungal Genet. Biol. 44, 1134-1145.

2006

Hoffmeister, D., Bechthold, A. (2006). Giftpflanzen, Pilzgifte. In: Aktories, K., Förstermann,
U., Hofmann, F., Starke, K. (Hrsg.), Repetitorium Pharmakologie und Toxikologie; Elsevier, 457-461.

Bok, J. W., Hoffmeister, D., Maggio-Hall, L., Murillo, R., Glasner, J., Keller, N. P. (2006). Genomic Mining for Aspergillus Natural Products. Chem. Biol. 13, 31-37.

2005

Merfort, I., Pelzer, S., Hoffmeister, D., Bechthold, A. (2005). Prokaryotic and eukaryotic cells in biotech production. In: Meyers, R. A. (Hrsg.), Encyclopedia of Molecular Cell Biology and Molecular Medicine; Vol. 10, 2nd edition; Wiley-VCH, 639-666.

Luzhetskyy, A., Zhu, L., Gibson, M., Fedoryshyn, M., Dürr, C., Hofmann, C., Hoffmeister, D., Ostash, B., Mattingly, C., Adams, V., Fedorenko, V. Rohr, J., Bechthold, A. (2005). Generation of novel Landomycins M and O through targeted gene disruption. Chembiochem 6, 675-678.

Chen, Y.-H., Wang, C.-C., Greenwell, L., Rix, U., Hoffmeister, D., Vining, L.C., Rohr, J., Yang, K.-Q. (2005). Functional Analyses of Oxygenases in Jadomycin Biosynthesis and Identification of JadH as a Bifunctional Oxygenase/Dehydrase. J. Biol. Chem. 280, 22508-22514.

2004

Hoffmeister, D., Bechthold, A. (2004). Kapitel 38.12 und 38.13 (Giftpflanzen, Pilzgifte). In: Aktories, K., Förstermann, U., Hofmann, F., Starke, K. (Hrsg.), Pharmakologie und Toxikologie. 9. Auflage; Elsevier, 1073-1089.

Yang, J., Hoffmeister, D., Liu, L., Fu, X., Thorson, J.S. (2004). The Tools for Natural Product Glycorandomization. Bioorg. Med. Chem. 12, 1577-1584.

Thorson, J.S., Barton, W.A., Hoffmeister, D., Albermann, C., Nikolov, D.B. (2004). Structure-Based Enzyme Engineering and Its Impact on In Vitro Glycorandomization. Chembiochem 5, 16-25.

Hoffmeister, D., Weber, M., Dräger, G., Ichinose, K., Dürr, C., Bechthold, A. (2004). Rational saccharide extension using the natural product glycosyltransferase LanGT4. Chembiochem 5, 369-371.

Dürr, C., Hoffmeister, D., Wohlert, S. E., Ichinose, K., Weber, M., von Mulert, U., Thorson, J. S., Bechthold, A. (2004). The Glycosyltransferase UrdGT2 establishes both O- and C-glycosidic bonds. Angewandte Chemie Intl. Ed. 43, 2962-2965.

Hoffmeister, D., Thorson, J. S. (2004). Mechanistic Implications of Escherichia coli Galactokinase Structure-Based Engineering. Chembiochem 5, 989-992.

2003

Pelzer, S., Hoffmeister, D., Merfort, I., Bechthold, A. (2003). Prokaryotic and eukaryotic cells in biotech production. In: Kayser, O., Müller, R. H. (Hrsg.), Pharmaceutical Biotechnology, Drug Discovery and Clinical Applications; Wiley-VCH, 9-33.

Rix, R., Remsing, L., Hoffmeister, D., Bechthold, A., Rohr, J. (2003). Urdamycin L, a novel metabolic shunt product, providing evidence for the role of the urdM Gene in the urdamycin A biosynthetic pathway by Streptomyces fradiae Tü 2717. Chembiochem 4, 109-111.

Hoffmeister, D., Dräger, G., Ichinose, K., Rohr, J., Bechthold, A. (2003). The C-glycosyltransferase UrdGT2 is unselective towards D- and L-configured nucleotide-bound rhodinoses. J. Am. Chem. Soc. 125, 4678-4679.

Rebets, Y., Ostash, B., Luzhetskyy, A., Hoffmeister, D., Brana, A., Mendez, C., Salas, J.A., Bechthold, A., Fedorenko, V. (2003). Production of landomycins in Streptomyces globisporus 1912 and S. cyanogenus S136 is regulated by genes encoding putative transcriptional activators. FEMS Lett. 222, 149-153.

Hoffmeister, D., Yang, J., Liu, L., Thorson, J.S. (2003). Creation of the First Anomeric D/L-Unspecific Sugar Kinase by Means of Directed Evolution. Proc. Nat. Acad. Sci. USA 100, 13184-13189.

2002

Hoffmeister, D., Bechthold, A., Pelzer, S. Wohlleben, W. (2002). Production of new natural substances by combinatorial biosynthesis. BIOspektrum 8, 508-511.

Hoffmeister, D., Wilkinson, B., Foster, G., Sidebottom, P.J., Ichinose, K., Bechthold, A. (2002). Engineered urdamycin glycosyltransferases are broadened and altered in substrate specificity. Chem. Biol. 9, 287-295.

Luzhetskyy, A., Fedoryshyn, M., Hoffmeister, D., Bechthold, A., Fedorenko, V. (2002). A gene cloning system for Streptomyces cyanogenus S136. Biovinsky (Ukraine) 29, 62-68.

2001

Hoffmeister, D., Ichinose, K., Bechthold, A. (2001). Two sequence elements of glycosyltransferases involved in urdamycin biosynthesis are responsible for substrate specificity and enzymatic activity. Chem. Biol. 8, 557-567.

Weitnauer, G., Mühlenweg, A., Trefzer, A., Hoffmeister, D., Süßmuth, R.D., Jung, G., Welzel, K., Vente, A., Girreser, U., Bechthold, A. (2001). Biosynthesis of the orthosomycin antibiotic avilamycin A: deductions from the molecular analysis of the avi biosynthetic gene cluster of Streptomyces viridochromogenes Tü57 and production of new antibiotics. Chem. Biol. 8, 569-581.

2000

Faust, B., Hoffmeister, D., Weitnauer, G., Westrich, L., Haag, S., Schneider, P., Decker, H., Künzel, E., Rohr, J., Bechthold, A. (2000). Two new tailoring enzymes, a glycosyltransferase and an oxygenase, involved in biosynthesis of the angucycline antibiotic urdamycin A in Streptomyces fradiae Tu2717. Microbiology 146, 147-153.

Trefzer, A., Hoffmeister, D., Künzel, E., Stockert, S., Weitnauer, G., Westrich, L., Rix, U., Fuchser, J., Bindseil, K.U., Rohr, J., Bechthold, A. (2000). Function of glycosyltransferase genes involved in urdamycin A biosynthesis. Chem. Biol. 7, 133-142.

Hoffmeister, D., Ichinose, K., Domann, S., Faust, B., Trefzer, A., Dräger, G., Kirschning, A., Fischer, C., Künzel, E., Bearden, D.W., Rohr, J., Bechthold, A. (2000). The NDP-sugar co-substrate concentration and the enzyme expression level influence the substrate specificity of glycosyltransferases: cloning and characterization of deoxysugar biosynthetic genes of the urdamycin biosynthetic gene cluster. Chem. Biol. 7, 821-831.

1999

Hoffmeister, D., Bechthold, A. (1999). Microbes: the search for new antibiotics. PZ Prisma 6, 185-194.

Unibund Halle - Leipzig - Jena Coimbragroup Partnerhochschule des Spitzensports