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263/2017 - Doctoral Researcher Position at the Jena Center for Soft Matter (Laboratory of Organic and Macromolecular Chemistry/Institute of Pharmaczeutical Technology


The Collaborative Research Center 1278 "PolyTarget - Polymer-based nanoparticle libraries for targeted anti-inflammatory strategies" will be funded by the Deutsche Forschungsgemeinschaft (DFG). The goal of PolyTarget is to develop polymer-based, nanoparticulate carrier materials for pharmaceutically active ingredients for targeted therapy of diseases and syndromes, whose morbidity is characterized by an inflammatory reaction. The integrated Research Training Group of PolyTarget is educating doctoral researchers in a structured, interdisciplinary training program. Close cooperation within the multi- and interdisciplinary consortium with researchers from Chemistry, Materials Science, Biology, Pharmacy and Medicine offers unique prerequisites for transferring the findings from basic research into applications (www.polytarget.uni-jena.de).

The Integrated Research Training Group of PolyTarget invites applications for a

Doctoral Researcher Position (m/f; Ref.-No. 263/2017)

at the Jena Center for Soft Matter (Laboratory of Organic and Macromolecular Chemistry, in cooperation with the Institute of Pharmaceutical Technology), Friedrich Schiller University Jena

Synthesis and formulation of polymeric nanoparticles for Raman spectroscopic characterization of their linkage- and interaction mechanism with hepatic stellate cells

The goal of the project is to develop nanoparticle systems based on synthetic and natural (polysaccharide) polymers that bear targeting functions for hepatic stellate cells, labeling functionalities for Raman investigations and drugs for hepatic stellate cell treatment. The synthesis of well-defined polymers using controlled polymerization techniques (e.g. RAFT, ATRP) and polymer analogous reactions is one focus of the PhD project. The second challenge is the formulation and characterization of appropriate nanoparticle systems. In a close cooperation with other scientists, the chemical sensitivity of linear and non-linear Raman-based imaging approaches will be utilized for the characterization of the interaction mechanism of nanoparticles and drugs with hepatic stellate cells and the investigation of their uptake kinetics.

Requirements:

  • A Master's degree (or equivalent) in e.g., polymer chemistry, synthetic organic chemistry or a related discipline; candidates expected to earn their degree before September 2017 are welcome to apply
  • Solid knowledge of controlled polymerization techniques, polymer functionalization, and use in life science settings together with associated characterization science
  • Excellent technical skills in e.g.: Analytical Chemistry, in particular mass spectrometry, and willingness to interdisciplinarily combine synthetic approaches with tailored polymer characterization approaches
  • Readyness to collaborate with short timescale work in the field and accompany implementation
  • Enthusiasm to play an active role in the interdisciplinary research team of PolyTarget
  • Highly motivated and creative personalities, with an interest to shape their own thesis project
  • Excellent written and oral communications skills in English

We offer:

  • A doctoral researcher position (TV‐L E13 ‐ salary agreement for public service employees, 50%) with funding from December 1, 2017, for 3 years, as well as generous research funding
  • Opportunity for research on an innovative and worldwide unique research platform
  • A comprehensive mentoring program with supervision by a team of advisors
  • A communicative atmosphere within a scientific network providing top‐level research facilities and training program, including participation in international and national conferences, summer schools and Workshops
  • The place of work is Jena, Germany, a young and lively university town with dynamic business activities, successful scientific centers of innovation, and a vibrant cultural scene around a university with a rich tradition

Severely disabled applicants with equal qualification and aptitude are given preferential consideration.

Applications should be written in English. The application deadline is September 30th, 2017.

Applications are submitted exclusively via e-mail to: jcsm@uni‐jena.de

Selected applicants will be invited to a recruitment meeting in Jena, Germany, presumably in October 2017.

For more information on the position, feel free to contact Dr. Stephanie Schubert (stephanie.schubert@uni‐jena.de). For more information on the application process, please contact the coordinator, michael.gottschaldt@uni‐jena.de). More project details: http://www.polytarget.uni‐jena.de.

 

Registriernummer
263/2017

 

Bewerbungsadresse
Friedrich-Schiller-Universität Jena
Laboratory of Organic and Macromolecular Chemistry
07743 - Jena

 

Ansprechpartner
Frau Dr. Stephanie Schubert
E-Mail:

 

Fristen
Ausschreibung vom: 13.09.2017
Bewerbungsende: 30.09.2017

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