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59/2018 - Doctoral Researcher Position at the Institut of Organic Chemistry and Macromolecular Chemistry

Ausschreibung Reg.-Nr.: 59/2018

Fristende: 20.02.2018

The Collaborative Research Center 1278 "PolyTarget - Polymer-based nanoparticle libraries for targeted anti-inflammatory strategies" is funded by the Deutsche Forschungsgemeinschaft (DFG). The goal of PolyTarget is to develop polymer-based, nanoparticulate carrier materials for pharmaceutically active ingredients for targeted therapy of diseases and syndromes, whose morbidity is characterized by an inflammatory reaction. The integrated Research Training Group of PolyTarget is educating doctoral researchers in a structured, interdisciplinary training program. Close cooperation within the multi- and interdisciplinary consortium with researchers from Chemistry, Materials Science, Biology, Pharmacy and Medicine offers unique prerequisites for transferring the findings from basic research into applications (

The Integrated Research Training Group of PolyTarget invites applications for a

Doctoral Researcher Position (m/f; Ref.-No. 59/2018)

at the Institute of Organic Chemistry and Macromolecular Chemistry, Friedrich Schiller University Jena

Macromolecular prodrug nanoparticles for antimicrobial therapy

This project aims at developing macromolecular prodrugs (MPDs) nanoparticle libraries containing two or more novel (or proprietary) drugs in well-defined ratios via the systematic synthesis and comprehensive high-throughput screening (HTS) of novel copolymer materials. Moreover, the introduction of cell-recognition moieties into the MPDs will lead to macrophage specific drug delivery systems. Ultimately, the MPDs will be equipped with phagolysosomes-targeting peptides to further enhance their activity. The use of HTS approaches in this project will enable to achieve an accelerated the selection of polymer and/or nanoparticle candidates with optimized molar mass, architecture, size, functionality and drug loading to enhance the delivery process of the selected anti-infective drugs.


  • A Master's degree (or equivalent) in e.g., polymer chemistry, synthetic organic chemistry or a related discipline; candidates expected to earn their degree before March 2018 are welcome to apply.
  • Solid knowledge of organic synthesis (preparation of monomers), reversible-deactivation radical polymerization techniques, kinetics of radical copolymerization, polymer functionalization and use in life science settings along with associated characterization and analytical techniques (such as NMR, SEC, DLS, DSC, TEM, GC, GC-MS, ESI-TOF, HPLC, etc.).
  • Experience in the use of automated parallel synthesizers would be a plus.
  • Readiness and enthusiasm to play an active and collaborative role to interdisciplinary work in short timescales with different scientists from other research teams of PolyTarget.
  • Highly motivated and creative personalities with an interest to shape their own thesis project.
  • Excellent written and oral communications skills in English.

We offer:

  • A doctoral researcher position (TV‐L E13 ‐ salary agreement for public service employees, 50 %) with funding from March 1, 2018, until Jun 30, 2021, as well as generous research funding
  • Opportunity for research on an innovative and worldwide unique research platform
  • A comprehensive mentoring program with supervision by a team of expert advisors
  • A communicative atmosphere within a scientific network providing top‐level research facilities and training program, including participation in international and national conferences, summer schools, workshops and/or research stays.
  • The place of work is Jena, Germany, a young and lively university town with dynamic business activities, successful scientific centers of innovation, and a vibrant cultural scene around a university with a rich tradition.

Severely disabled applicants with equal qualification and aptitude are given preferential consideration.

Applications should be written in English. The application deadline is February 20th, 2018.

Applications are submitted exclusively via e-mail to: jcsm@uni‐

Selected applicants will be invited to a recruitment meeting in Jena, Germany, presumably end of February 2018.

For more information on the position, feel free to contact Prof. Dr. Ulrich S. Schubert (ulrich.schubert@uni‐ or Dr. Carlos Guerrero Sanchez (). For more information on the application process, please contact the coordinator, michael.gottschaldt@uni‐ More project details: http://www.polytarget.uni‐



Friedrich-Schiller-Universität Jena
Institut of Organic Chemistry and Macromolecular Chemistry


Prof. Dr. Ulrich Schubert


Ausschreibung vom: 07.02.2018
Bewerbungsende: 20.02.2018

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