Prof. Dr. Thomas Winckler
Publikationen - Publications
M. Espinoza-Moraga, J. Caballero, F. Gaube, T. Winckler, L.S. Santos (2012). 1-Benzyl-1,2,3,4-tetrahydro-β-carboline as channel blocker of N-methyl-D-aspartate receptors. Chem. Biol. Drug Design 79, 594-599
A. Asghar, M. Groth, O. Siol, F. Gaube, C. Enzensperger, G. Glöckner & T. Winckler (2012). Developmental gene regulation by an ancient intercellular communication system in social amoebae. Protist 163, 25-37
2011
T. Winckler, J. Schiefner, T. Spaller & O. Siol (2011). Dictyostelium transfer RNA gene-targeting retrotransposons - Studying mobile element-host interactions in a compact genome. Mobile Genet. Elements 1(2), 145-150
O. Siol, T. Spaller, J. Schiefner & T. Winckler (2011). Genetically tagged TRE5-A retrotransposons reveal high amplification rates and authentic target site preference in the Dictyostelium discoideum genome. Nuc. Acids Res. 39(15), 6608-6619
T. Winckler (2011). Virale Gentransfer-Arzneimittel. Pharm. Unserer Zeit 40(3), 202-211
T. Winckler (2011). Systematik und Biologie der Hepatitis-Viren. Pharm. Unserer Zeit 40(1), 14-24
A. Bilzer, H. Dölz, A. Reinhardt, A. Schmith, O. Siol & T. Winckler (2011). The C-module-binding factor supports the amplification of TRE5-A retrotransposons in the Dictyostelium discoideum genome. Euk. Cell 10, 81-86
2010
T. Dingermann, T. Winckler & I. Zündorf (2010). Gentechnik - Biotechnik. 2. Auflage. Wissenschaftliche Verlagsgesellschaft Stuttgart, ISBN 978-3-8047-2534-8
B. Tewes, B. Frehland, D. Schepmann, K.-U. Schmidtke, T. Winckler & B. Wünsch (2010). Conformationally constrained NR2B selective NMDA receptor antagonists derived from ifenprodil: Synthesis and biolgical evaluation of tetrahydro-3-benzazepine-1,7-diols. Bioorg. Med. Chem. 18, 8005-8015
Y. Rook, K.-U. Schmidtke, F. Gaube, D. Schepmann, B. Wünsch, J. Heilmann, J. Lehmann & T. Winckler (2010). Bivalent beta-carbolines as potential multi-target anti-Alzheimer agents. J. Med. Chem. 53, 3611-3617
B. Tewes, B. Frehland, D. Schepmann, K.-U. Schmidtke, T. Winckler & B. Wünsch (2010). Design, synthesis and pharmacological evaluation of 3-benzazepin-1-ols as NR2B-selective NMDA receptor antagenosts. ChemMedChem 5, 687-695
2009
J. Lucas, A. Bilzer, L. Moll, I. Zündorf, T. Dingermann, L. Eichinger, O. Siol & T. Winckler (2009). The carboxy-terminal domain of Dictyostelium C-module-binding factor is an independent gene regulatory entity. PLoS ONE 4(4), e5012
T. Winckler (2009). Abschlussbericht des IQWiG zu Ginkgo biloba. Patienten profitieren von der Therapie. Pharm. Unserer Zeit 38(5), 454-461
2008
T. Winckler, I. Zündorf & T. Dingermann (2008). Protein-Tyrosinkinasen als Wirkstoff-Targets. Pharm. Unserer Zeit 37(5), 370-380
2007
T. Chung, O. Siol, T. Dingermann & T. Winckler (2007). Proteininteractions involved in tRNA gene-specific integration of Dictyostelium non-long terminal repeat retrotransposon TRE5-A. Mol.Cell. Biol. 27, 8492-8501
2006
P. Schaap, T. Winckler, M. Nelson, E. Alvarez-Curto, B. Elgie, H. Hagiwara, J. Cavender, A. Milano-Curto, D.E. Rozen, T. Dingermann, R. Mutzel & S.L. Baldauf (2006). Molecular phylogeny and evolution of morphology in the social amoebas. Science 314, 661-663
O. Siol, M. Boutliliss, T. Chung, G. Glöckner, T. Dingermann & T. Winckler (2006). Role of RNA polymerase III transcription factors in the selection of integration sites by the Dictyostelium non-long terminal repeat retrotransposon TRE5-A. Mol. Cell. Biol. 26, 8242-8251
O. Siol, T. Dingermann & T. Winckler (2006). The C-module DNA-binding factor mediates expression of the Dictyostelium aggregation-specific adenylyl cyclase ACA. Eukaryot. Cell 5, 658-664
2005
T. Winckler, I. Zündorf & T. Dingermann (2005). An NIH model organism for biopharmaceutical and biomedical research: the lower eukaryote Dictyostelium discoideum; in: Modern Biopharmaceuticals - Design, Development and Optimization (Vol. 2), J. Knäblein (ed.), Wiley VCH, pp.661-693
T. Winckler, K. Szafranski & G. Glöckner (2005). Transfer RNA gene-targeted integration: an adaptation of retrotransposable elements to survive in the compact Dictyostelium discoideum genome. Cytogenet. Genome Res. 110, 288-298
L. Eichinger, J.A. Pachebat, G. Glöckner, M.-A. Rajandream, R. Sucgang, M. Berriman, J. Song, R. Olsen, K. Szafranski, Q. Xu, B. Tunggal, S. Kummerfeld, M. Madera, B. A. Konfortov, F. Rivero, A. T. Bankier, R. Lehmann, N. Hamlin, R. Davies, P. Gaudet, P. Fey, K. Pilcher, G. Chen, D. Saunders, E. Sodergren, P. Davis, A. Kerhornou, X. Nie, N. Hall, C. Anjard, L. Hemphill, N. Bason, P. Farbrother, B. Desany, E. Just, T. Morio, R. Rost, C. Churcher, J. Cooper, S. Haydock, N. van Driessche, A. Cronin, I. Goodhead, D. Muzny, T. Mourier, A. Pain, M. Lu, D. Harper, R. Lindsay, H. Hauser, K. James, M. Quiles, M. Madan Babu, T. Saito, C. Buchrieser, A. Wardroper, M. Felder, M. Thangavelu, D. Johnson, A. Knights, H. Loulseged, K. Mungall, K. Oliver, C. Price, M.A. Quail, H. Urushihara, J. Hernandez, E. Rabbinowitsch, D. Steffen, M. Sanders, J. Ma, Y. Kohara, S. Sharp, M. Simmonds, S. Spiegler, A. Tivey, S. Sugano, B. White, D. Walker, J. Woodward, T. Winckler, Y. Tanaka, G. Shaulsky, M. Schleicher, G. Weinstock, A. Rosenthal, E.C. Cox, R. L. Chisholm, R. Gibbs, W. F. Loomis, M. Platzer, R. R. Kay, J. Williams, P. H. Dear, A.A. Noegel, B. Barrell & A. Kuspa (2005). The genome of the social amoeba Dictyostelium discoideum. Nature 435, 43-57
2004
T. Winckler, N. Iranfar, P. Beck, I. Jennes, O. Siol, U. Baik, W.F. Loomis & T. Dingermann (2004). CbfA, the C-module DNA-binding factor, plays an essential role in the initiation of Dictyostelium discoideum development. Eukaryot. Cell 3, 1349-1358
K. Szafranski, T. Dingermann, G. Glöckner & T. Winckler (2004). Template jumping by a Dictyostelium LINE reverse transcriptase created a SINE-like 5S rRNA retropseudogene. Mol. Gen. Genomics 271, 98-102
2003
K. Dannat, J. Tillner, T. Winckler, M. Weiß, K. Eger, & T. Dingermann (2003). The effects of medicinal compounds on the differentiation of the eukaryotic microorganism Dictyostelium discoideum: Can this method be used as a screening test for reproductive toxicity in humans? Pharmazie 58, 204-210
P. Beck & T. Winckler (2003). Das Wandern ist der Transposons Lust - Grundlagenforschung für die Gentherapie, Deutsche Apotheker Zeitung 143(7), 52-61
P. Beck & T. Winckler (2003). Retrotransposons im Dictyostelium-Genom - Konzept für die Gentherapie? BioForum 3/2003
2002
T. Winckler, T. Dingermann & G. Glöckner (2002). Dictyostelium mobile elements - strategies to amplify in a compact genome. Cell. Mol. Life Sci. 59, 2097-2111
G. Glöckner, L. Eichinger, K. Szafranski, J.A. Pachebat, A.T. Bankier, P.H. Dear, R. Lehmann, C. Baumgart, G. Parra, J.F. Abril, R. Guigó, K. Kumpf, B.Tunggal, the Dictyostelium Genome Sequencing Consortium (u.a. T. Winckler), E. Cox, M.A. Quail, M. Platzer, A. Rosenthal & A.A. Noegel (2002). Sequence and analysis of chromosome 2 of Dictyostelium discoideum. Nature 418, 79-85
A. Friese, K. Hell-Momeni, I. Zündorf, T. Winckler, T. Dingermann & G. Dannhardt (2002). Synthesis and biological evaluation of cycloalkylidene carboxylic acids as novel effectors of Ras/Raf interaction. J. Med. Chem. 45, 1535-1542
P. Beck, T. Dingermann & T. Winckler (2002). Transfer RNA gene-targeted retrotransposition of Dictyostelium TRE5-A into a chromosomal UMP synthase gene trap. J. Mol. Biol. 318, 273-285
2001
U. Hentschel, I. Zündorf, T. Dingermann & T. Winckler (2001). On the problem of establishing the subcellular localization of Dictyostelium retrotransposon TRE5-A proteins by biochemical analysis of nuclear extracts. Anal. Biochem. 296, 83-91
T. Winckler, C. Trautwein, C. Tschepke, C. Neuhäuser, I. Zündorf, G. Vogel & T. Dingermann (2001). Gene function analysis by amber stop codon suppression: CMBF is a nuclear protein that supports growth and development of Dictyostelium amoebae. J. Mol. Biol. 305, 703-714
G. Glöckner, K. Szafranski, T. Winckler, T. Dingermann, M. Quail, E. Cox, L. Eichinger, A.A. Noegel & A. Rosenthal (2001). The complex repeats of Dictyostelium discoideum. Genome Res. 11, 585-594
1999
J. Horn, A. Dietz-Schmidt, I. Zündorf, J. Garin, T. Dingermann & T. Winckler (1999). A Dictyostelium protein binds to distinct oligo(dA)•oligo(dT) DNA sequences in the C-module of the retrotransposable element DRE. Eur. J. Biochem. 265, 441-448
K. Szafranski, G. Glöckner, T. Dingermann, A.A. Noegel, L. Eichinger, A. Rosenthal & T. Winckler (1999). Non-LTR retrotransposons with unique integration preferences downstream of Dictyostelium discoideum transfer RNA genes. Mol. Gen. Genet. 262, 772-780
H.-T. Wolf, T. van den Berg, F.-C. Czygan, A. Mosandl, T. Winckler, I. Zündorf & T. Dingermann (1999). Identification of Melissa officinalis subspecies by DNA fingerprinting. Planta Med. 65, 83-85
H.-T. Wolf, I. Zündorf, T. Winckler, R. Bauer & T. Dingermann (1999). Characterization of Echinacea species and detection of possible adulterations by RAPD analysis. Planta Med. 65, 773-774
1998
T. Winckler (1998). Retrotransposable elements in the Dictyostelium discoideum genome. Cell. Mol. Life Sci. 54, 383-393
T. Winckler, C. Tschepke., E.L. de Hostos, A. Jendretzke & T. Dingermann (1998). Tdd-3, a transfer RNA gene-associated poly(A) retrotransposon from Dictyostelium discoideum. Mol. Gen. Genet. 257, 655-661
J. Tillner, H. Nau, T. Winckler & T. Dingermann (1998). Evaluation of the teratogenic potential of valproic acid analogues in transgenic Dictyostelium discoideum strains. Toxicol. in Vitro 12, 463-469
G. Voith, H. Kramm, I. Zündorf, T. Winckler & T. Dingermann (1998). Expression of the rat muscarinic receptor gene m3 in Dictyostelium discoideum. Pharmazie 53, 707-710
1997
M. Bukenberger, J. Horn, T. Dingermann, R.P. Dottin & T. Winckler (1997). Molecular cloning of a cDNA encoding nucleosome core histone H3 from Dictyostelium discoideum by genetic selection in yeast. Biochim. Biophys. Acta 1352, 85-90
1996
A. Geier, J. Horn, T. Dingermann & T. Winckler (1996). A nuclear protein factor binds to the 3' regulatory module of the long-interspersed-nuclear-element-like Dictyostelium repetitive element. Eur. J. Biochem. 241, 70-76
J. Tillner, T. Winckler & T. Dingermann (1996). Developmentally regulated promoters from Dictyostelium discoideum as molecular markers for testing potential teratogens. Pharmazie 51, 902-906
1994
M. Bukenberger, T. Dingermann, W. Meissner, K.H. Seifart & T. Winckler (1994). Isolation of transcription factor IIIC from Dictyostelium discoideum. Eur. J. Biochem. 220, 839-846
J. Tillner,T. Winckler & T. Dingermann (1994). A simple cytotoxicity assay using the eucaryotic microorganism Dictyostelium discoideum. Pharmazie 49, 759-761
1993
J. Hofmann, T. Winckler, A. Hanenkamp, M. Bukenberger, G. Schumann, R. Marschalek & Dingermann, T. (1993). The Dictyostelium discoideum 5S rDNA is organized in the same transcriptional orientation as the other rDNAs. Biochem. Biophys. Res. Comm.191, 558-564
H. Troll, T. Winckler, I. Lascu, N. Müller, W. Saurin, M. Véron & R. Mutzel (1993). Separate nuclear genes encode cytosolic and mitochondrial nucleoside diphosphate kinase in Dictyostelium discoideum. J. Biol. Chem. 268, 25469-2547
1992
M.-N. Simon, T. Winckler, R. Mutzel, M. Véron & J.C.C. Maia (1992). Serine/threonine protein phosphatases in Dictyostelium discoideum: No evidence for type 1 activity. Biochem. Biophys. Res. Comm. 184, 1142-1151
1991
T. Winckler, H. Dammann & Mutzel, R. (1991). Ca2+/calmodulin-binding proteins in Dictyostelium discoideum. Res. Microbiol. 142, 509-519
J. Sonnemann, A. Bäuerle, T. Winckler & R. Mutzel (1991). A ribosomal calmodulin-binding protein from Dictyostelium. J. Biol. Chem. 266, 23091-23096