An einem Fluoreszenzmikroskop werden Gehirnstrukturen eines Zebrafischembryos untersucht.

What time is it on your biological clock?

Interdisciplinary research team receives up to 4.5 million euros in funding from the Carl Zeiss Foundation
Brain structures of a zebrafish embryo are examined under a fluorescence microscope.
Image: Jens Meyer (University of Jena)
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Published: 8 October 2020, 12:00 | By: Ute Schönfelder

As the saying goes: “You’re only as old as you feel”, suggesting that it is not simply the number of years lived that determines a person’s age. Biological age depends on many factors and is also subject to psychological influences. It is perfectly possible for contemporaries to differ in the way they perceive their physical and mental ages: a mind that remains youthful and agile can have a positive effect on physical fitness, while the opposite can also be true.

How biological age is defined, how it can be exactly calculated and which factors influence the complex aging processes in humans – this is what the IMPULS research project of Friedrich Schiller University Jena aims to find out. The project team is being supported over five years by a grant of up to 4.5 million euros from the Carl Zeiss Foundation as part of the “Breakthroughs” programme.

Comprehensive look at the aging process

IMPULS stands for “Identification and manipulation of the physiological and psychological clocks of the lifespan” (Identifizierung und Manipulation der physiologischen und psychologischen Uhren der Lebensspanne). In their project, the researchers therefore want to discover not only how “late” it currently is on a person’s biological clock. “We also want to know whether and how aging can be slowed down through manipulation of the biological clock,” explains Christoph Englert, coordinator of the joint project. The Professor of Molecular Genetics at the University of Jena and research group leader at the Leibniz Institute on Aging – Fritz Lipmann Institute (FLI) says that aging processes are modulated by individual factors such as nutrition, lifestyle and personal perceptions of age. “By linking physiology and psychology, we wish to develop a new perspective on aging,” he adds.

The project partners specifically want to use studies on humans, but also on various model organisms, to determine new criteria for age determination at the molecular and neurobiological level. In addition, they want to study the effects of physiological factors on aging, for example the influence of sport on brain aging or of nutrition on age-related inflammation. By measuring brain structure, among other things, the researchers want to find out whether psychological stress or the personal experience of aging has an effect on the biological clock. And last but not least, ethical implications of the possible results form part of the research project: what will it mean if life expectancy and age-related diseases can be predicted more accurately in future? How will society’s view of age change if in future we can also define it biologically and not just chronologically?

In addition to researchers on aging, the project team includes experts in biochemistry, epigenetics, medicine, neuroscience, nutritional science, pharmacy, epidemiology, bioinformatics, biostatistics, psychology and social sciences.

Dr. Birgit Perner von der Arbeitsgruppe "Molekulare Genetik" des Instituts für Alternsforschung - Fritz-Lipmann-Institut (FLI) - untersucht an einem Stereo-Fluoreszenz-Mikroskop die Entwicklung der Blutgefäße im Kopf einer Fischlarve. Die Verwendung von Modellorganismen sowie bildgebende Verfahren spielen eine wichtige Rolle im IMPULS-Konsortium. Dr Birgit Perner from the "Molecular Genetics" research group at the Leibniz Institute on Aging – Fritz Lipmann Institute - uses a stereo fluorescence microscope to investigate the development of the blood vessels in the head of a fish larva. Using model organisms and imaging techniques play an important role in the IMPULS consortium. Image: Jens Meyer (University of Jena)

Contact:

Christoph Englert, Prof. Dr
Leibniz-Institut für Alternsforschung – Fritz-Lipmann-Institut (FLI)
Beutenbergstraße 11
07745 Jena
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